The UV/Visible Radiation Boundary Region (385–405 nm) Damages Skin Cells and Induces “dark” Cyclobutane Pyrimidine Dimers in Human Skin in vivo.
5 September 2018
The adverse efects of terrestrial solar ultraviolet radiation (UVR) (~295–400nm) on the skin are well documented, especially in the UVB region (~295–320nm). The efects of very long-wave UVA (>380nm) and visible radiation (≥400nm) are much less known. Sunscreens have been benefcial in inhibiting a wide range of photodamage, however most formulations provide very little protection in the long wave UVA region (380–400nm) and almost none from shortwave visible wavelengths (400–420nm).
We demonstrate photodamage in this region for a number of diferent endpoints including cell viability, DNA damage (delayed cyclobutane pyrimidine dimers), diferential gene expression (for genes associated with infammation, oxidative stress and photoageing) and induction of oxidizing species in vitro in HaCaT keratinocytes and in vivo in human volunteers. This work has implications for phototherapy and photoprotection.
Lawrence, K.P., Douki, T., Sarkany, R.P., Acker, S., Herzog, B. and Young, A.R., 2018. The UV/Visible Radiation Boundary Region (385–405 nm) Damages Skin Cells and Induces “dark” Cyclobutane Pyrimidine Dimers in Human Skin in vivo. Scientific reports, 8(1), pp.12722-12722.
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