In this work, we performed the synthesis and characterization of a new class of drug delivery system denominated magnetic nanoemulsion (MNE), which allows the combined action of photodynamic therapy (PDT) and hyperthermia therapy (HPT), designed to work in a synergic way, leading to an expected enhancement of the tumor damage after minimum doses of heat dissipation and/or visible light photosensitization.
The MNEs were prepared by mixture of two surfactants among the following: Epikuron 170 or Span 80/Poloxamer 188 or Tween 80. The magnetic nanoparticles (MNPs) used in this study are maghemite surface-coated with phosphate (PPT) and the photosensitizer used is Zinc phthalocyanine derivative (ZnPc).
Macaroff, P.P., Primo, F.L., Lacava, Z.G.M., Morais, P.C. and Tedesco, A.C., 2006. Synthesis and characterization of a magnetic nanoemulsion as a promising candidate for cancer treatment. IEEE transactions on magnetics, 42(10), pp.3596-3598.
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