Beneficial effects of photo-inactive titanium dioxide specimens on plasmid DNA, human cells and yeast cells exposed to UVA/UVB simulated sunlight.

Abstract

Photoactive TiO₂ specimens extracted from commercial sunscreen lotions had been shown earlier [R. Dunford, A. Salinaro, L. Cai, N. Serpone, S. Horikoshi, H. Hidaka, J. Knowland, FEBS Lett. 418 (1997) 87] to cause damage to both DNA plasmids in vitro and to whole human skin cells in cultures by photoproduced OH radicals. This article reports on the effects of TiO₂ specimens, whose particle surface was modified by a thermally assisted procedure to produce TiO₂ specimens of considerably reduced photo-activity.

Deactivation of the photocatalytic activity of TiO₂ impacts on the kinetics of photooxidation of phenol and has a significant effect in diminishing, if not suppressing completely, damage caused to DNA plasmids, to human cells, and to yeast cells compared to non-modified specimens exposed to UVB/UVA simulated solar radiation. Photo-inactive TiO₂ could be beneficial in sunscreen formulations and in polymer blends, since they also completely retain their UVB/UVA absorption/scattering (screening) characteristics.

Synergistic effects of titania specimens with an organic sunscreen active agent (Padimate-O) on DNA plasmids and the survival of yeast cells in the presence of titanium dioxide, and in the presence of such UV filters as Padimate-O and Parsol 1789 (i.e., avobenzone) under UV irradiation are reported.

Citation

Serpone, N., Salinaro, A., Horikoshi, S. and Hidaka, H., 2006. Beneficial effects of photo-inactive titanium dioxide specimens on plasmid DNA, human cells and yeast cells exposed to UVA/UVB simulated sunlight. Journal of Photochemistry and Photobiology A: Chemistry, 179(1), pp.200-212.

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Category: Material & Chemical

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